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Introduction: Although many studies have demonstrated the existing neurological symptoms in COVID-19 patients, the mechanisms are not clear until now. This study aimed to figure out the critical molecular and immune infiltration situations in the brain of elderly COVID-19 patients. Methods: GSE188847 was used for the differential analysis, WGCNA, and immune infiltration analysis. We also performed GO, KEGG, GSEA, and GSVA for the enrich analysis. Results: 266 DEGs, obtained from the brain samples of COVID-19 and non-COVID-19 patients whose ages were over 70 years old, were identified. GO and KEGG analysis revealed the enrichment in synapse and neuroactive ligand-receptor interaction in COVID-19 patients. Further analysis found that asthma and immune system signal pathways were significant changes based on GSEA and GSVA. Immune infiltration analysis demonstrated the imbalance of CD8+ T cells, neutrophils, and HLA. The MEpurple module genes were the most significantly different relative to COVID-19. Finally, RPS29, S100A10, and TIMP1 were the critical genes attributed to the progress of brain damage. Conclusion: RPS29, S100A10, and TIMP1 were the critical genes in the brain pathology of COVID-19 in elderly patients. Our research has revealed a new mechanism and a potential therapeutic target.
Subject(s)
Asthma , Brain Injuries , COVID-19 , Aged , Humans , COVID-19/genetics , Brain , Genes, RegulatorABSTRACT
Objective: To explore the pharmacological mechanism of Jinyebaidu Particles in the treatment of coronavirus disease 2019(COVID-19).
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In response to the ministry of education proposed measure "suspended class, ongoing learning" under the COVID- 19 epidemic. Taking the course of Medical Immunology as an example, this article discusses the implementation of "full online" teaching mode facing the particularity during coronavirus pneumonia epidemic, cultivation of scientific and humanistic spirit and the inspiration of students' curiosity by introducing hot issues in epidemic life. This paper provides case and reference for the distance teaching of medical immunology in local colleges and universities.
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The world is in the grip of the COVID-19 caused by SARS-Cov-2 pandemic. Public health measures that can reduce the risk of infection and death in addition to quarantines are desperately needed. Malnutrition and various non-communicable underlying diseases, such as obesity, diabetes mellitus, cardiovascular diseases, leading to immunodeficiency in patients are important risk factors for severe COVID-19. Special nutrient supplement have pharmacological effect, stimulate the immune cells in a particular way, strengthen the function of immune response, maintain appropriate immune response, adjustment of cytokine production and release, reduce harmful or excessive inflammation, have positive sense to the prognosis of patients with COVID-19. This article reviewed the role of immune nutrients such as vitamins, mineral elements, polyunsaturated fatty acids, dietary fiber in reducing the risk of respiratory tract infections, as well as the current application of immunonutrition in COVID-19, in order to provide reliable reference for the adjuvant role of immunonutrition in the comprehensive treatment of COVID-19.